Traditionally, people with darker hair and skin color who do not sunburn easily were classified as lower risk for skin cancer. But new research is showing that even people with these traits can be at high risk for melanoma, based on their genetic factors. Researchers at the University of Pennsylvania have discovered that variations in the melanocortin 1 receptor (MC1R), a molecule that controls skin pigmentation, in individuals with dark features can actually increase their melanoma risk by 2.4-fold. Although no test is currently available to detect whether one has a MC1R variant, this genetic contribution to melanoma risk will definitely be considered when stratifying individuals for skin cancer risk in the future.
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Tags: MC1R, melanocortin, melanoma, skin, skin cancer, sunburn
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Dr. Steven Chang, the author of DailyDose, is a staff physician with Kosmix RightHealth. Dr. Chang practices Family Medicine at the University of California Davis Medical Center, where his medical interests include both pediatric and geriatric care, public health, gay and lesbian health, and sleep medicine. Dr. Chang trained at the Stanford University affiliated O'Connor Hospital, and was a research fellow at the National Institute of Health. He holds an M.D. from McGill University and a BA in Public Health from Johns Hopkins University.
April 24th, 2009 at 1:15 am
Really? That is good to know, because I always think I’m in the clear since I don’t burn! I’ll be more careful…
February 7th, 2010 at 6:49 am
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