Posts Tagged ‘gout’

We know that a diet high in sugar can contribute to obesity, which in turn can cause hypertension. But now scientists have discovered that sugar, especially fructose, can have a direct bearing on one’s blood pressure. The connection? Uric acid. If you have gout, you probably know a bit about uric acid. It’s the substance that builds up in joints during a painful gout attack. But it seems that uric acid can also inhibit the production of nitric oxide, a compound that is essential for keeping our blood vessels flexible – when our blood vessels are less flexible and compliant, hypertension sets in. Researchers tested this theory by placing subjects on a high-fructose diet and giving some of them allopurinol, a drug commonly used to reduce uric acid levels in patients with gout. Those who weren’t on the drug had a 6 mm Hg-increase in systolic blood pressure and a 3 mm Hg-increase in diastolic pressure, compared to those on allopurinol. These findings were presented at the American Heart Association’s High Blood Pressure Research Conference in Chicago. [via ABC News]

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If you have gout you can attest to how painful gout flares can be. Even the diagnosis of gout can be painful because the only definitive way to diagnose the disease is to stick a needle into the inflamed joint, take a sample of the fluid, and look at it under the microscope to find the characteristic gout crystals. However, a new technique being developed at the Vancouver General Hospital may prove to be an accurate and noninvasive way to diagnose gout. By using a CT scanner with two x-ray tubes that can simultaneously produce different energies, researchers were able to detect the presence of gout crystals even in patients without symptoms. This is certainly a very promising and welcomed accomplishment. Gout currently affects over 2 million people in the US.

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The results of a 20-year-long study has been published in the March 9th issue of the Archives of Internal Medicine. Researchers followed over 45,000 men and assessed their vitamin C intake throughout the length of the study and found that for every 500 milligram increase in vitamin C consumption, men’s risk for gout appeared to decrease by 17 percent. Men in the study who took 1,500 mg per day had a 45 percent less risk of gout, compared to those who took less than 250 mg per day. The researchers conclude that “Given the general safety profile associated with vitamin C intake, particularly in the generally consumed ranges as in the present study…vitamin C intake may provide a useful option in the prevention of gout,”

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The US Food and Drug Administration has given approval to the first new gout drug to appear on the market in 40 years. Gout is an intensely painful form of arthritis. The new drug, febuxostat, will be marketed in the US under the name Uloric by Takeda Pharmaceuticals. Febuxostat lower the concentration of uric acid in the blood of people with gout. It has been shown to be effective in clinical trials and is safe for patient with kidney or liver problems.

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